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| カタログ番号 | MF739013 |
|---|---|
| 種反応性 | Mouse |
| アプリケーション | Blocking, IHC |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | HJ6.3 |
| ターゲット | Apo-E, Apolipoprotein E, APOE |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P08226 |
| RRID | Anti-Mouse APOE Antibody (HJ6.3) (abinScience Cat# MF739013, RRID:AB_3725650) |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | Apolipoprotein E (APOE) is a ~35 kDa protein. APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. 1. Gonzales, JC. et al. (2013) The Journal of clinical investigation 123, 2742-51. PMID: 23676495 |
| 注意事項 | For research use only. |
SEC-HPLC detection for Anti-Mouse APOE Antibody (HJ6.3).
SDS-PAGE for Anti-Mouse APOE Antibody (HJ6.3).
Western blot analysis was performed using anti-APOE monoclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse liver lysate
Lane 2: Mouse brain lysate
Lane 3: Mouse heart lysate
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