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| カタログ番号 | MD635014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse CCDC88B Polyclonal Antibody (MD635014) is a rabbit polyclonal antibody detecting Ccdc88b. Suitable for Mouse.
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse CCDC88B (Met1-Leu236). | ||||||||
| ターゲット | Ccdc88, Ccdc88b, Coiled-coil domain-containing protein 88B, Gipie, HkRP3, Hook-related protein 3 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q4QRL3 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Coiled-coil domain-containing protein 88B (CCDC88B) is a ~166 kDa protein. Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation and during the course of infection with the mouse malaria parasite Plasmodium berghei. Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC. Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis. 1. Kennedy, JM. et al. (2014) The Journal of experimental medicine 211, 2519-35. PMID: 25403443 2. Matsushita, E. et al. (2011) Molecular biology of the cell 22, 736-47. PMID: 21289099 | ||||||||
| 注意事項 | For research use only |
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