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| カタログ番号 | MX131013 |
|---|---|
| 種反応性 | Mouse |
| アプリケーション | ELISA, Neutralization |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG2a, kappa |
| クローンID | SAA2679 |
| ターゲット | Beta-chemokine exodus-1, C-C motif chemokine 20, CC chemokine LARC, CC chemokine ST38, Ccl20, Larc, Liver and activation-regulated chemokine, MIP-3-alpha, Macrophage inflammatory protein 3 alpha, Scya20, Small-inducible cytokine A20 |
| エンドトキシンレベル | <10 EU/mg |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | O89093 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | C-C motif chemokine 20 (CCL20/MIP-3-alpha) is a ~10 kDa protein. Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. 1. Röhrl, J. et al. (2010) The Journal of biological chemistry 285, 7028-34. PMID: 20068036 2. Varona, R. et al. (1998) FEBS letters 440, 188-94. PMID: 9862452 3. Ito, T. et al. (2011) Experimental cell research 317, 613-9. PMID: 21376174 4. Yamazaki, T. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 8391-401. PMID: 19050256 5. Bunting, MD. et al. (2014) Immunology and cell biology 92, 489-98. PMID: 24638065 6. Diao, R. et al. (2014) Science translational medicine 6, 249ra108. PMID: 25122636 7. Tanaka, Y. et al. (1999) European journal of immunology 29, 633-42. PMID: 10064080 |
| 注意事項 | For research use only |
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