Anti-Mouse CCL20/MIP-3-alpha Recombinant Antibody (SAA2679) (MX131013)

Name: Anti-Mouse CCL20/MIP-3-alpha Recombinant Antibody (SAA2679)
Brand: abinScience
SKU: MX131013
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Каталожный номер	MX131013
Реактивность видов	Mouse
Применения	ELISA, Neutralization
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG2a, kappa
ID клона	SAA2679
Цель	Beta-chemokine exodus-1, C-C motif chemokine 20, CC chemokine LARC, CC chemokine ST38, Ccl20, Larc, Liver and activation-regulated chemokine, MIP-3-alpha, Macrophage inflammatory protein 3 alpha, Scya20, Small-inducible cytokine A20
Уровень эндотоксинов	<10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	O89093
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	C-C motif chemokine 20 (CCL20/MIP-3-alpha) is a ~10 kDa protein. Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. 1. Röhrl, J. et al. (2010) The Journal of biological chemistry 285, 7028-34. PMID: 20068036 2. Varona, R. et al. (1998) FEBS letters 440, 188-94. PMID: 9862452 3. Ito, T. et al. (2011) Experimental cell research 317, 613-9. PMID: 21376174 4. Yamazaki, T. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 8391-401. PMID: 19050256 5. Bunting, MD. et al. (2014) Immunology and cell biology 92, 489-98. PMID: 24638065 6. Diao, R. et al. (2014) Science translational medicine 6, 249ra108. PMID: 25122636 7. Tanaka, Y. et al. (1999) European journal of immunology 29, 633-42. PMID: 10064080
Примечание	For research use only

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Даташит

Anti-Mouse CCL20/MIP-3-alpha Recombinant Antibody (SAA2679).pdf

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