

| Numéro de catalogue | MW620013 | ||||
|---|---|---|---|---|---|
| Reactivité des espèces | Mouse | ||||
| Applications | ELISA, FCM, Functional assay, Research in vivo | ||||
| Espèce hôte | Rat | ||||
| Clonalité | Monoclonal | ||||
| Isotype | IgG2b, kappa | ||||
| ID de clone | 6S2-19-4 | ||||
| Cible | C C CKR3, C-C CKR-3, C-C chemokine receptor type 3, CC-CKR-3, CCR-3, CCR3, CD193, CKR 3, CKR3, CMKBR3, Eosinophil eotaxin receptor | ||||
| Niveau d'endotoxines | < 10 EU/mg | ||||
| Pureté | >95% as determined by SDS-PAGE. | ||||
| Produits associés | pH 7.4 Dilution Buffer | ||||
| Purification | Protein A/G purified from cell culture supernatant. | ||||
| Numéro d'accès | P51678 | ||||
| Forme | Liquid | ||||
| Tampon de stockage | 0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Expédition | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. | ||||
| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| Contexte | Probable C-C chemokine receptor type 3 (CCR3/CD193) is a ~41 kDa protein. G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines. Selectively interacts with eosinophil-attracting chemokines such as eotaxin/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. Ligand binding triggers intracellular signaling that leads to chemotaxis of immune cells. Mechanistically, signals through GNA14 or GNA16 to induce stimulation of phospholipase Cbeta/PLCB2 and subsequently chemotaxis. Alternatively, transduces signal via GNAI1 resulting in elevated intracellular calcium levels and activation of the PI3K/AKT pathway. | ||||
| Note | For research use only |
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