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| カタログ番号 | MW601014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse CD110/MPL Polyclonal Antibody (MW601014) is a rabbit polyclonal antibody detecting CD110 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse CD110/MPL (Ser394-Ile483). | ||||||||
| ターゲット | Thrombopoietin receptor, TPO-R, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD110, Mpl, Tpor | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q08351 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Thrombopoietin receptor (CD110/MPL) is a ~69 kDa protein. Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production. 1. Alexander, WS. et al. (1996) Blood 87, 2162-70. PMID: 8630375 2. Drachman, JG. et al. (1997) Proceedings of the National Academy of Sciences of the United States of America 94, 2350-5. PMID: 9122198 3. Solar, GP. et al. (1998) Blood 92, 4-10. PMID: 9639492 | ||||||||
| 注意事項 | For research use only. |
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