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| カタログ番号 | MB714014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse CD123/IL3RA Polyclonal Antibody (MB714014) is a rabbit polyclonal antibody detecting CD123 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse CD123/IL3RA (Asp49-Cys323). | ||||||||
| ターゲット | IL-3R subunit alpha, IL-3 receptor subunit alpha, CD123, Interleukin-3 receptor subunit alpha, IL3R, IL-3R-alpha, IL3RA, IL-3RA | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P26952 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Interleukin-3 receptor subunit alpha (CD123/IL-3Rα) is a ~43 kDa protein. Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program. 1. Orban, PC. et al. (1999) Blood 94, 1614-22. PMID: 10477686 2. Tong, Y. et al. (2020) JCI insight 5. PMID: 31990690 3. Jaster, R. et al. (1999) Cellular signalling 11, 331-5. PMID: 10376805 | ||||||||
| 注意事項 | For research use only. |
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