

| Número de catálogo | MY038014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-Mouse CD14 Polyclonal Antibody (MY038014) is a rabbit polyclonal antibody detecting CD14 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| Reactividad de especies | Mouse | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Mouse CD14 (Glu21-Gly322). | ||||||||
| Objetivo | CD14, Monocyte differentiation antigen CD14, Monocyte differentiation antigen CD14, membrane-bound form, Monocyte differentiation antigen CD14, urinary form, My23 antigen, Myeloid cell-specific leucine-rich glycoprotein | ||||||||
| Nivel de endotoxinas | Please contact with the lab for this information. | ||||||||
| Pureza | >90% as determined by SDS-PAGE. | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | P10810 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Monocyte differentiation antigen CD14 is a ~39 kDa protein. Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Acts as an accessory receptor for M.tuberculosis lipoproteins LprA, LprG and LpqH, in conjunction with coreceptors TLR2 and TLR1. 1. Gangloff, SC. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 175, 3940-5. PMID: 16148141 2. Jiang, Z. et al. (2005) Nature immunology 6, 565-70. PMID: 15895089 3. Haziot, A. et al. (1996) Immunity 4, 407-14. PMID: 8612135 4. Drage, MG. et al. (2009) Cellular immunology 258, 29-37. PMID: 19362712 | ||||||||
| Nota | For research use only. |
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