Anti-Mouse NKG2A/CD159a Polyclonal Antibody (MB188014)

Name: Anti-Mouse NKG2A/CD159a Polyclonal Antibody
Brand: abinScience
SKU: MB188014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Vista general

Número de catálogo

MB188014

Descripción

Anti-Mouse NKG2A/CD159a Polyclonal Antibody (MB188014) is a rabbit polyclonal antibody detecting NKG2A/CD159a in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Mouse CD159a/KLRC1 (Glu131-Ile244).

Objetivo

Killer cell lectin-like receptor subfamily C, member 1, Natural killer cell protein group 2-A1, Natural killer cell receptor NKG2A, Klrc1, Nkg2a

Purificación

Purified by antigen affinity column.

Número de acceso

Q9Z202

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

NKG2-A/NKG2-B type II integral membrane protein (CD159a/KLRC1) is a ~26 kDa protein. Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions.

1. Sullivan, LC. et al. (2007) Immunity 27, 900-11. PMID: 18083576

2. Lin, Z. et al. (2023) Nature immunology 24, 1087-1097. PMID: 37264229

3. Valiante, NM. et al. (1997) Immunity 7, 739-51. PMID: 9430220

4. Braud, VM. et al. (1998) Nature 391, 795-9. PMID: 9486650

5. Kabat, J. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 169, 1948-58. PMID: 12165520

6. Le Dréan, E. et al. (1998) European journal of immunology 28, 264-76. PMID: 9485206

7. Kamiya, T. et al. (2019) The Journal of clinical investigation 129, 2094-2106. PMID: 30860984

8. Jabri, B. et al. (2002) Immunity 17, 487-99. PMID: 12387742

9. Bhagat, G. et al. (2008) The Journal of clinical investigation 118, 281-93. PMID: 18064301

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Mouse NKG2A/CD159a Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

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