中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | MV234014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse CD169/SIGLEC1 Polyclonal Antibody (MV234014) is a rabbit polyclonal antibody detecting SIGLEC1. Suitable for Mouse.
|
||||||||
| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse CD169/SIGLEC1 (Gly22-Val235). | ||||||||
| ターゲット | CD169, SIGLEC1, SN, Sialic acid-binding Ig-like lectin 1, Sialoadhesin, Siglec-1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q62230 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 背景 | Sialoadhesin (CD169/SIGLEC1) is a ~182 kDa protein. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response. Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs). In turn, enhances macrophage-to-T-cell transmission of several viruses including murine leukemia virus. Acts as an endocytic receptor mediating clathrin dependent endocytosis. 1. Chang, YC. et al. (2014) Journal of molecular medicine (Berlin, Germany) 92, 951-9. PMID: 24788876 2. Erikson, E. et al. (2015) The Journal of biological chemistry 290, 27345-27359. PMID: 26370074 | ||||||||
| 注意事項 | For research use only |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
