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Обзор
Каталожный номерMB896014
Описание
Anti-Mouse CD191/CCR1 Polyclonal Antibody (MB896014) is a rabbit polyclonal antibody detecting C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CD191; Ccr1; Cmkbr1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Реактивность видовMouse
ПримененияELISA, IHC, WB
Хозяинский видRabbit
КлоональностьPolyclonal
ИзотипIgG
Иммуноген E. coli - derived recombinant mouse CD191/CCR1 (Glu2-Ala34&Asp92-Lys107&Phe172-Arg197&Gln265-Leu281).
Цель C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CD191; Ccr1; Cmkbr1
Уровень эндотоксинов Please contact with the lab for this information.
Чистота >95% as determined by SDS-PAGE.
Очистка Purified by antigen affinity column.
Номер доступа P51675
Форма Liquid
Буфер хранения 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта
Применение Разбавление
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Устойчивость и хранение Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон

C-C chemokine receptor type 1 (CD191/CCR1) is a ~40 kDa protein. Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine. For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF and leukotriene B4. Also mediates monocyte migration upon CXCL4 binding.

1. Gao, JL. et al. (1997) The Journal of experimental medicine 185, 1959-68. PMID: 9166425
2. Ramos, CD. et al. (2005) Journal of leukocyte biology 78, 167-77. PMID: 15831559
3. Yan, J. et al. (2020) Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 17, 1170-1183. PMID: 31898284
Примечание For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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