Anti-Mouse CCR8 Polyclonal Antibody (MW444014)

Name: Anti-Mouse CCR8 Polyclonal Antibody
Brand: abinScience
SKU: MW444014
Price: 168 USD
Availability: InStock

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Aperçu

Numéro de catalogue

MW444014

Description

Anti-Mouse CD198/CCR8 Polyclonal Antibody (MW444014) is a rabbit polyclonal antibody detecting C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; CDw198; Ccr8; Cmkbr8; Ter1 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant mouse CD198/CCR8 (Asp2-Met33&Asn92-Lys105&Tyr170-Ile200&His262-Leu278).

Cible

C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; CDw198; Ccr8; Cmkbr8; Ter1

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

P56484

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

C-C chemokine receptor type 8 (CD198/CCR8) is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage by supporting lymphoid cells IFN-gamma production.

1. Goya, I. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 1975-81. PMID: 9469461

2. Chensue, SW. et al. (2001) The Journal of experimental medicine 193, 573-84. PMID: 11238588

3. Kang, L. et al. (2020) Frontiers in immunology 11, 609400. PMID: 33613532

Note

For research use only

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