

| Каталожный номер | MV765014 | ||||||||
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| Описание |
Anti-Mouse LAIR1 Polyclonal Antibody (MV765014) is a rabbit polyclonal antibody detecting LAIR1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| Реактивность видов | Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Mouse CD305/LAIR1 (Gly24-Lys117). | ||||||||
| Цель | Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (mLAIR1) (CD antigen CD305) | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q8BG84 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Leukocyte-associated immunoglobulin-like receptor 1 (CD305/LAIR1) is a ~29 kDa protein. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. | ||||||||
| Примечание | For research use only. |




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