

| Numéro de catalogue | MB856147 |
|---|---|
| Reactivité des espèces | Human, Mouse, Rat |
| Applications | ELISA, FCM |
| Espèce hôte | Rat |
| Clonalité | Monoclonal |
| Isotype | IgG1, kappa |
| ID de clone | U3-1784 |
| Conjugaison | PerCP |
| Cible | FGFR4, Fibroblast growth factor receptor 4, TKF, FGFR-4, JTK2, CD334 |
| Niveau d'endotoxines | Please contact with the lab for this information. |
| Produits associés | Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), PerCP |
| Numéro d'accès | Q03142 |
| Forme | Liquid |
| Tampon de stockage | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
| Stabilité et stockage | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| Contexte | Fibroblast growth factor receptor 4 (CD334/FGFR4) is a ~88 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. |
| Note | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |




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