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| カタログ番号 | MB030014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse CD36 (Lys56-Gly423). | ||||||||
| ターゲット | Cd36 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q08857 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Platelet glycoprotein 4 (CD36) is a ~52 kDa protein. Multifunctional glycoprotein that acts as a receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). 1. Endemann, G. et al. (1993) The Journal of biological chemistry 268, 11811-6. PMID: 7685021 2. Jimenez-Dalmaroni, MJ. et al. (2009) PloS one 4, e7411. PMID: 19847289 3. Stewart, CR. et al. (2010) Nature immunology 11, 155-61. PMID: 20037584 4. Heit, B. et al. (2013) Developmental cell 24, 372-83. PMID: 23395392 5. Wang, J. et al. (2019) Cell reports 26, 209-221.e5. PMID: 30605677 6. Hao, JW. et al. (2020) Nature communications 11, 4765. PMID: 32958780 7. Nassir, F. et al. (2007) The Journal of biological chemistry 282, 19493-501. PMID: 17507371 8. Masuda, D. et al. (2009) Journal of lipid research 50, 999-1011. PMID: 18753675 9. Tran, TT. et al. (2011) The Journal of biological chemistry 286, 25201-10. PMID: 21610069 10. Laugerette, F. et al. (2005) The Journal of clinical investigation 115, 3177-84. PMID: 16276419 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-CD36 polyclonal antibody at 1µg/ml on various samples.
Lane 1: Mouse lung lysate
Lane 2: Mouse heart lysate
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