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| カタログ番号 | MV829014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse Dectin-1/CLEC7A Polyclonal Antibody (MV829014) is a rabbit polyclonal antibody detecting Dectin-1/CLEC7A in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse CD369/CLEC7A (Asn122-Leu244). | ||||||||
| ターゲット | C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369) | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q6QLQ4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | C-type lectin domain family 7 member A (CD369/CLEC7A) is a ~27 kDa protein. Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. 1. Brown, GD. et al. (2001) Nature 413, 36-7. PMID: 11544516 2. Adachi, Y. et al. (2004) Infection and immunity 72, 4159-71. PMID: 15213161 3. Taylor, PR. et al. (2007) Nature immunology 8, 31-8. PMID: 17159984 4. Gantner, BN. et al. (2003) The Journal of experimental medicine 197, 1107-17. PMID: 12719479 5. Viriyakosol, S. et al. (2005) Infection and immunity 73, 1553-60. PMID: 15731053 6. Yadav, M. et al. (2006) Blood 108, 3168-75. PMID: 16825490 7. Campuzano, A. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 204, 3296-3306. PMID: 32358020 8. Rogers, NC. et al. (2005) Immunity 22, 507-17. PMID: 15845454 | ||||||||
| 注意事項 | For research use only. |
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