Anti-Mouse CD69 Polyclonal Antibody (MC273014)

Name: Anti-Mouse CD69 Polyclonal Antibody
Brand: abinScience
SKU: MC273014
Price: 168 USD
Availability: InStock

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Vista general

Número de catálogo

MC273014

Descripción

Anti-Mouse CD69 Polyclonal Antibody (MC273014) is a rabbit polyclonal antibody detecting CD69 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Mouse CD69 (His81-Arg199).

Objetivo

Early activation antigen CD69 (CD antigen CD69)

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

P37217

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Early activation antigen CD69 is a ~22 kDa protein. Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types. Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells. Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage. Also acts via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells.

1. Martín, P. et al. (2010) Molecular and cellular biology 30, 4877-89. PMID: 20696842

2. Bui, DV. et al. (2024) Biomolecules 14. PMID: 38540778

3. Shiow, LR. et al. (2006) Nature 440, 540-4. PMID: 16525420

Nota

For research use only.

Imágenes

Referencias

Datasheet