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| カタログ番号 | MW630137 |
|---|---|
| ブランド | abinScience |
| 種反応性 | Mouse, Canine |
| アプリケーション | FCM |
| 宿主種 | Armenian Hamster |
| クローン性 | Monoclonal |
| アイソタイプ | IgG |
| クローンID | 16-10A1 |
| 抱合 | APC |
| ターゲット | CD80, BB1, T-lymphocyte activation antigen CD80, CD28LG, B7, CD28LG1, LAB7, Activation B7-1 antigen, CTLA-4 counter-receptor B7.1 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| アクセッション番号 | Q00609 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | T-lymphocyte activation antigen CD80 (B7-1) is a ~34 kDa protein. Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells. In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway. 1. Tseng, SY. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 175, 7829-36. PMID: 16339518 2. Freeman, GJ. et al. (1991) The Journal of experimental medicine 174, 625-31. PMID: 1714935 3. Good-Jacobson, KL. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 188, 4217-25. PMID: 22450810 |
| 注意事項 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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