

| Каталожный номер | MW549014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Mouse CDKN1A Polyclonal Antibody (MW549014) is a rabbit polyclonal antibody detecting Cdkn1a in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| Реактивность видов | Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Mouse CDKN1A (Ser2-Pro159). | ||||||||
| Цель | Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein, p21, Cdkn1a, Cip1, Waf1 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P39689 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Cyclin-dependent kinase inhibitor 1 (p21/CDKN1A) is a ~17 kDa protein. May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding. 1. Esteve-Puig, R. et al. (2014) PLoS genetics 10, e1004721. PMID: 25329316 | ||||||||
| Примечание | For research use only. |

Lane 1: Mouse heart lysate
Lane 2: Rat heart lysate
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