Anti-Mouse CLEC6A Polyclonal Antibody (MA366014)

Name: Anti-Mouse CLEC6A Polyclonal Antibody
Brand: abinScience
SKU: MA366014
Price: 168 USD
Availability: InStock

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100ug

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Número de catálogo

MA366014

Descripción

Anti-Mouse CLEC6A Polyclonal Antibody (MA366014) is a rabbit polyclonal antibody detecting CLEC6A in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Mouse CLEC6A (Ile44-Leu209).

Objetivo

DC-associated C-type lectin 2, DECTIN2, Dendritic cell-associated C-type lectin 2, CLECSF10, CLEC6A, C-type lectin domain family 6 member A, C-type lectin superfamily member 10, Dectin-2

Purificación

Purified by antigen affinity column.

Número de acceso

Q9JKF4

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

C-type lectin domain family 6 member A (CLEC6A) is a ~24 kDa protein. Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Also recognizes, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses.

1. Sato, K. et al. (2006) The Journal of biological chemistry 281, 38854-66. PMID: 17050534

2. Robinson, MJ. et al. (2009) The Journal of experimental medicine 206, 2037-51. PMID: 19703985

3. Saijo, S. et al. (2010) Immunity 32, 681-91. PMID: 20493731

4. Campuzano, A. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 204, 3296-3306. PMID: 32358020

5. Barrett, NA. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 1119-28. PMID: 19124755

6. Ritter, M. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 20459-64. PMID: 21059925

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Mouse CLEC6A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Mouse CLEC6A Polyclonal Antibody (MA366014)

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Imágenes

Referencias

Datasheet

SDS