中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | MC461014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse DSG2 Polyclonal Antibody (MC461014) is a rabbit polyclonal antibody detecting DSG2 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
|
||||||||
| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse DSG2 (Val61-Asn386). | ||||||||
| ターゲット | CDHF5, HDGC, Desmoglein-2, DSG2, Cadherin family member 5 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O55111 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Desmoglein-2 (DSG2) is a ~122 kDa protein. A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development. Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes. Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells. 1. Eshkind, L. et al. (2002) European journal of cell biology 81, 592-8. PMID: 12494996 2. Park, J. et al. (2018) Stem cell reports 11, 115-127. PMID: 29910125 3. Ebert, LM. et al. (2016) Angiogenesis 19, 463-86. PMID: 27338829 4. Kant, S. et al. (2015) Circulation. Cardiovascular genetics 8, 553-63. PMID: 26085008 5. Myo Min, KK. et al. (2022) Cell death & disease 13, 911. PMID: 36309486 6. Xu, T. et al. (2024) Kidney international 105, 1035-1048. PMID: 38395410 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
