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Anti-Mouse VEGFR1/Flt-1 Recombinant Antibody (AbIII), FITC (MB265117)

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Vista general
Número de catálogoMB265117
Reactividad de especiesMouse
AplicacionesELISA, FCM
Especie huéspedRat
ClonalidadMonoclonal
IsotipoIgG1, kappa
ID de clonAbIII
ConjugaciónFITC
Objetivo FLT1, Vascular endothelial growth factor receptor 1, VEGFR1, Vascular permeability factor receptor, FRT, Tyrosine-protein kinase receptor FLT, VEGFR-1, FLT, FLT-1, Tyrosine-protein kinase FRT, Fms-like tyrosine kinase 1
Nivel de endotoxinas Please contact with the lab for this information.
Productos asociados Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), FITC
Número de acceso P35969
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Estabilidad y almacenamiento Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo

Vascular endothelial growth factor receptor 1 (FLT1/VEGFR1) is a ~149 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific.

1. Nguyen, MT. et al. (2019) Nature cell biology 21, 420-429. PMID: 30936473
Nota For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.
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