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Anti-Mouse FOLR1 Polyclonal Antibody (MB825014)

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Número de catálogoMB825014
Descripción
Anti-Mouse FOLR1 Polyclonal Antibody (MB825014) is a rabbit polyclonal antibody detecting FOLR1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesMouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Mouse FOLR1 (Asp53-Ser198).
Objetivo Folate receptor alpha, FOLR, FOLR1, Adult folate-binding protein, Folate receptor 1, FR-alpha, KB cells FBP, FBP, Ovarian tumor-associated antigen MOv18, Folate receptor, adult
Purificación Purified by antigen affinity column.
Número de acceso P35846
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Folate receptor alpha (FOLR1) is a ~29 kDa protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption. FOLR1 is the therapeutic target of mirvetuximab soravtansine (Elahere).

1. Brigle, KE. et al. (1991) The Journal of biological chemistry 266, 17243-9. PMID: 1894617
2. Piedrahita, JA. et al. (1999) Nature genetics 23, 228-32. PMID: 10508523
3. Tang, LS. et al. (2003) Birth defects research. Part A, Clinical and molecular teratology 67, 209-18. PMID: 12854656
4. Tang, LS. et al. (2004) Birth defects research. Part A, Clinical and molecular teratology 70, 449-58. PMID: 15259034
5. Zhu, H. et al. (2007) Birth defects research. Part A, Clinical and molecular teratology 79, 257-68. PMID: 17286298
6. Birn, H. et al. (2005) Journal of the American Society of Nephrology : JASN 16, 608-15. PMID: 15703271
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Mouse FOLR1 Polyclonal Antibody

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