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| カタログ番号 | MB825014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse FOLR1 Polyclonal Antibody (MB825014) is a rabbit polyclonal antibody detecting FOLR1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse FOLR1 (Asp53-Ser198). | ||||||||
| ターゲット | Folate receptor alpha, FOLR, FOLR1, Adult folate-binding protein, Folate receptor 1, FR-alpha, KB cells FBP, FBP, Ovarian tumor-associated antigen MOv18, Folate receptor, adult | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P35846 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Folate receptor alpha (FOLR1) is a ~29 kDa protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption. FOLR1 is the therapeutic target of mirvetuximab soravtansine (Elahere). 1. Brigle, KE. et al. (1991) The Journal of biological chemistry 266, 17243-9. PMID: 1894617 2. Piedrahita, JA. et al. (1999) Nature genetics 23, 228-32. PMID: 10508523 3. Tang, LS. et al. (2003) Birth defects research. Part A, Clinical and molecular teratology 67, 209-18. PMID: 12854656 4. Tang, LS. et al. (2004) Birth defects research. Part A, Clinical and molecular teratology 70, 449-58. PMID: 15259034 5. Zhu, H. et al. (2007) Birth defects research. Part A, Clinical and molecular teratology 79, 257-68. PMID: 17286298 6. Birn, H. et al. (2005) Journal of the American Society of Nephrology : JASN 16, 608-15. PMID: 15703271 | ||||||||
| 注意事項 | For research use only. |
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