Anti-Mouse FOLR1 Polyclonal Antibody (MB825014)

Name: Anti-Mouse FOLR1 Polyclonal Antibody
Brand: abinScience
SKU: MB825014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

MB825014

Описание

Anti-Mouse FOLR1 Polyclonal Antibody (MB825014) is a rabbit polyclonal antibody detecting FOLR1 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Mouse FOLR1 (Asp53-Ser198).

Цель

Folate receptor alpha, FOLR, FOLR1, Adult folate-binding protein, Folate receptor 1, FR-alpha, KB cells FBP, FBP, Ovarian tumor-associated antigen MOv18, Folate receptor, adult

Очистка

Purified by antigen affinity column.

Номер доступа

P35846

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Folate receptor alpha (FOLR1) is a ~29 kDa protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption. FOLR1 is the therapeutic target of mirvetuximab soravtansine (Elahere).

1. Brigle, KE. et al. (1991) The Journal of biological chemistry 266, 17243-9. PMID: 1894617

2. Piedrahita, JA. et al. (1999) Nature genetics 23, 228-32. PMID: 10508523

3. Tang, LS. et al. (2003) Birth defects research. Part A, Clinical and molecular teratology 67, 209-18. PMID: 12854656

4. Tang, LS. et al. (2004) Birth defects research. Part A, Clinical and molecular teratology 70, 449-58. PMID: 15259034

5. Zhu, H. et al. (2007) Birth defects research. Part A, Clinical and molecular teratology 79, 257-68. PMID: 17286298

6. Birn, H. et al. (2005) Journal of the American Society of Nephrology : JASN 16, 608-15. PMID: 15703271

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Mouse FOLR1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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