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| カタログ番号 | MV370014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse FPN1/SLC40A1/Ferroportin Polyclonal Antibody (MV370014) is a rabbit polyclonal antibody detecting Ferroportin-1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse FPN1/SLC40A1/Ferroportin (Thr230-Pro306). | ||||||||
| ターゲット | Solute carrier family 40 member 1, Ferroportin-1, Iron-regulated transporter 1, Metal transporter protein 1, MTP1, Slc40a1, Fpn1, Ireg1, Slc11a3, Slc39a1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9JHI9 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ferroportin (FPN1/SLC40A1) is a ~62 kDa protein. Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis. Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes. When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma. 1. Donovan, A. et al. (2005) Cell metabolism 1, 191-200. PMID: 16054062 2. Zhang, DL. et al. (2018) Blood 132, 2078-2087. PMID: 30213870 | ||||||||
| 注意事項 | For research use only. |
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