Anti-Mouse GDF-15 Polyclonal Antibody (MV986014)

Name: Anti-Mouse GDF-15 Polyclonal Antibody
Brand: abinScience
SKU: MV986014
Price: 96 USD
Availability: InStock

Datasheet Compartir producto Copiar información

Precio(USD):

Especificación:

20ug
50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

MV986014

Descripción

Anti-Mouse GDF-15 Polyclonal Antibody (MV986014) is a rabbit polyclonal antibody detecting GDF-15 in ELISA, IHC, WB. Suitable for Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Mouse GDF15/MIC1 (Gly203-Ala303).

Objetivo

Growth/differentiation factor 15, GDF-15, Macrophage inhibitory cytokine 1, MIC-1

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Purified by antigen affinity column.

Número de acceso

Q9Z0J7

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Growth/differentiation factor 15 (GDF15/MIC1) is a ~33 kDa protein. Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea and/or loss of appetite. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions. The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues.

1. Tsai, VW. et al. (2013) PloS one 8, e55174. PMID: 23468844

2. Chung, HK. et al. (2017) The Journal of cell biology 216, 149-165. PMID: 27986797

3. Wang, T. et al. (2017) EMBO molecular medicine 9, 1150-1164. PMID: 28572090

4. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097

5. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098

6. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099

7. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886

8. Tsai, VW. et al. (2018) International journal of obesity (2005) 42, 561-571. PMID: 29026214

9. Xiong, Y. et al. (2017) Science translational medicine 9. PMID: 29046435

10. Patel, S. et al. (2019) Cell metabolism 29, 707-718.e8. PMID: 30639358

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Mouse GDF-15 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo