Anti-Mouse GDF-15 Polyclonal Antibody (MV986014)

Name: Anti-Mouse GDF-15 Polyclonal Antibody
Brand: abinScience
SKU: MV986014
Price: 96 USD
Availability: InStock

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Каталожный номер

MV986014

Описание

Anti-Mouse GDF-15 Polyclonal Antibody (MV986014) is a rabbit polyclonal antibody detecting GDF-15 in ELISA, IHC, WB. Suitable for Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Mouse GDF15/MIC1 (Gly203-Ala303).

Цель

Growth/differentiation factor 15, GDF-15, Macrophage inhibitory cytokine 1, MIC-1

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Purified by antigen affinity column.

Номер доступа

Q9Z0J7

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Growth/differentiation factor 15 (GDF15/MIC1) is a ~33 kDa protein. Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea and/or loss of appetite. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions. The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues.

1. Tsai, VW. et al. (2013) PloS one 8, e55174. PMID: 23468844

2. Chung, HK. et al. (2017) The Journal of cell biology 216, 149-165. PMID: 27986797

3. Wang, T. et al. (2017) EMBO molecular medicine 9, 1150-1164. PMID: 28572090

4. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097

5. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098

6. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099

7. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886

8. Tsai, VW. et al. (2018) International journal of obesity (2005) 42, 561-571. PMID: 29026214

9. Xiong, Y. et al. (2017) Science translational medicine 9. PMID: 29046435

10. Patel, S. et al. (2019) Cell metabolism 29, 707-718.e8. PMID: 30639358

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Mouse GDF-15 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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