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| カタログ番号 | MS720014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse GFRAL Polyclonal Antibody (MS720014) is a rabbit polyclonal antibody detecting Gfral. Suitable for Mouse and Rat.
Highlights
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| 種反応性 | Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse GFRAL (Met128-Asn318). | ||||||||
| ターゲット | GDNF family receptor alpha-like, Gfral, Gral | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q6SJE0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | GDNF family receptor alpha-like (GFRAL) is a ~43 kDa protein. Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin. Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways. Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. 1. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097 2. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098 3. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099 4. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886 5. Tsai, VW. et al. (2019) International journal of obesity (2005) 43, 2370-2380. PMID: 31152154 6. Borner, T. et al. (2020) Cell metabolism 31, 351-362.e5. PMID: 31928886 7. Worth, AA. et al. (2020) eLife 9. PMID: 32723474 8. Sabatini, PV. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 33593916 9. Lu, JF. et al. (2022) PLoS biology 20, e3001517. PMID: 35202387 10. Benichou, O. et al. (2023) Cell metabolism 35, 274-286.e10. PMID: 36630958 | ||||||||
| 注意事項 | For research use only |
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