Anti-Mouse GFR alpha-like Polyclonal Antibody (MS720014)

Name: Anti-Mouse GFR alpha-like Polyclonal Antibody
Brand: abinScience
SKU: MS720014
Price: 168 USD
Availability: InStock

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Каталожный номер

MS720014

Описание

Anti-Mouse GFRAL Polyclonal Antibody (MS720014) is a rabbit polyclonal antibody detecting Gfral. Suitable for Mouse and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Mouse GFRAL (Met128-Asn318).

Цель

GDNF family receptor alpha-like, Gfral, Gral

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

Q6SJE0

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Фон

GDNF family receptor alpha-like (GFRAL) is a ~43 kDa protein. Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin. Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways. Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem.

1. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097

2. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098

3. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099

4. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886

5. Tsai, VW. et al. (2019) International journal of obesity (2005) 43, 2370-2380. PMID: 31152154

6. Borner, T. et al. (2020) Cell metabolism 31, 351-362.e5. PMID: 31928886

7. Worth, AA. et al. (2020) eLife 9. PMID: 32723474

8. Sabatini, PV. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 33593916

9. Lu, JF. et al. (2022) PLoS biology 20, e3001517. PMID: 35202387

10. Benichou, O. et al. (2023) Cell metabolism 35, 274-286.e10. PMID: 36630958

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-Mouse GFR alpha-like Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

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Anti-Mouse GFR alpha-like Polyclonal Antibody (MS720014)

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