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| カタログ番号 | MW691014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse GGT5 Polyclonal Antibody (MW691014) is a rabbit polyclonal antibody detecting Ggt5 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse GGT5 (Ser30-Tyr573). | ||||||||
| ターゲット | Glutathione hydrolase 5 proenzyme, 3.4.19.13, Gamma-glutamyl leukotrienase, GGL, Gamma-glutamyltransferase 5, GGT 5, 2.3.2.2, Gamma-glutamyltransferase-like activity 1, Gamma-glutamyltranspeptidase 5, Leukotriene-C4 hydrolase, 3.4.19.14, Glutathione hydrolase 5 heavy chain, Glutathione hydrolase 5 light chain, Ggt5, Ggtla1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Z2A9 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Glutathione hydrolase 5 proenzyme (GGT5) is a ~61 kDa protein. Cleaves the gamma-glutamyl bond of extracellular glutathione tripeptide (gamma-Glu-Cys-Gly) and certain glutathione conjugates. Hydrolyzes glutathione releasing L-Glu and Cys-Gly dipeptide which is further metabolized to maintain extracellular cysteine levels but also to provide cysteine necessary for intracellular glutathione synthesis. Among glutathione-S-conjugates metabolizes leukotriene C4 (LTC4) and S-geranylgeranyl-glutathione (GGG), but is inactive toward gamma-glutamyl leucine. Converts extracellular LTC4 to LTD4 during acute inflammatory response. Acts as a negative regulator of GGG bioactivity. 1. Shi, ZZ. et al. (2001) Molecular and cellular biology 21, 5389-95. PMID: 11463821 2. Han, B. et al. (2002) The American journal of pathology 161, 481-90. PMID: 12163373 3. Lu, E. et al. (2019) Nature 567, 244-248. PMID: 30842656 4. Carter, BZ. et al. (1998) The Journal of biological chemistry 273, 28277-85. PMID: 9774450 5. Gallman, AE. et al. (2021) Science immunology 6. PMID: 34088745 | ||||||||
| 注意事項 | For research use only. |
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