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| カタログ番号 | MW310013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Mouse | ||||
| アプリケーション | Blocking, ELISA, FCM | ||||
| 宿主種 | Rat | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG1 | ||||
| クローンID | 7C8 | ||||
| テスト済みアプリケーション | WB | ||||
| ターゲット | GPC3, MXR7, GTR2-2, Glypican-3, Intestinal protein OCI-5, OCI5 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q8CFZ4 | ||||
| RRID | Anti-Mouse GPC3 Antibody (7C8) (abinScience Cat# MW310013, RRID:AB_3725638) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Glypican-3 (GPC3/Glypican 3) is a ~65 kDa protein. Cell surface proteoglycan. Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins. Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation. Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands. Positively regulates the non-canonical Wnt signaling pathway. 1. Capurro, MI. et al. (2008) Developmental cell 14, 700-11. PMID: 18477453 2. Bhave, VS. et al. (2013) The American journal of pathology 183, 153-9. PMID: 23665349 3. Song, HH. et al. (2005) The Journal of biological chemistry 280, 2116-25. PMID: 15537637 4. Paine-Saunders, S. et al. (2000) Developmental biology 225, 179-87. PMID: 10964473 5. Grisaru, S. et al. (2001) Developmental biology 231, 31-46. PMID: 11180950 6. Ng, A. et al. (2009) Developmental biology 335, 208-15. PMID: 19733558 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Mouse GPC3 Antibody (7C8).
Lane 1: HepG2 cell lysate
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