

| Numéro de catalogue | MF993014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Mouse H6PD Polyclonal Antibody (MF993014) is a rabbit polyclonal antibody detecting H6pd in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| Reactivité des espèces | Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Mouse H6PD (Ser551-Gly789). | ||||||||
| Cible | GDH/6PGL endoplasmic bifunctional protein, Hexose-6-phosphate dehydrogenase, Glucose 1-dehydrogenase, 1.1.1.47, Glucose-6-phosphate dehydrogenase, 1.1.1.363, 6-phosphogluconolactonase, 6PGL, 3.1.1.31, H6pd | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q8CFX1 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | GDH/6PGL endoplasmic bifunctional protein (H6PD) is a ~88 kDa protein. Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway. May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate. The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum. 1. Clarke, JL. et al. (2003) Archives of biochemistry and biophysics 415, 229-34. PMID: 12831846 2. Lavery, GG. et al. (2006) The Journal of biological chemistry 281, 6546-51. PMID: 16356929 3. Lavery, GG. et al. (2008) The Journal of biological chemistry 283, 8453-61. PMID: 18222920 4. Beutler, E. et al. (1967) The Journal of biological chemistry 242, 5289-93. PMID: 4169027 | ||||||||
| Note | For research use only. |
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