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| カタログ番号 | MY200013 | ||||
|---|---|---|---|---|---|
| ブランド | abinScience | ||||
| 種反応性 | Bovine, Canine, Equine, Porcine | ||||
| アプリケーション | FCM, FuncS, IF, WB | ||||
| 宿主種 | Rat | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG1, kappa | ||||
| クローンID | DPH1.1 | ||||
| ターゲット | High mobility group protein B1, HMGB1, HMG1, HMG-1, High mobility group protein 1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P63158 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. | ||||
| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | High mobility group protein B1 (HMGB1) is a ~24 kDa protein. Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. 1. Yang, H. et al. (2013) Journal of leukocyte biology 93, 865-73. PMID: 23446148 2. Li, G. et al. (2013) Frontiers in immunology 4, 68. PMID: 23519706 3. Li, G. et al. (2013) Seminars in cancer biology 23, 380-90. PMID: 23994764 4. Lee, SA. et al. (2014) Yonsei medical journal 55, 1165-76. PMID: 25048472 5. Mitola, S. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 176, 12-5. PMID: 16365390 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Mouse HMGB1 Antibody (DPH1.1)
Western blot analysis was performed using anti-HMGB1 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human HMGB1 (Catalog No: HY200011)
Lane 2: negative control
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