Anti-Mouse HMGB1 Recombinant Antibody (DPH1.1) (MY200013)

Name: Anti-Mouse HMGB1 Recombinant Antibody (DPH1.1)
Brand: abinScience
SKU: MY200013
Price: 126 USD
Availability: InStock

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Цена(USD):

Спецификация:

20ug
50ug
100ug
1mg

Количество:

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

MY200013

Бренд

abinScience

Реактивность видов

Bovine, Canine, Equine, Porcine

Применения

FCM, FuncS, IF, WB

Хозяинский вид

Rat

Клоональность

Monoclonal

Изотип

IgG1, kappa

ID клона

DPH1.1

Цель

High mobility group protein B1, HMGB1, HMG1, HMG-1, High mobility group protein 1

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Protein A/G purified from cell culture supernatant.

Номер доступа

P63158

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Реконституция

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Информация об использовании продукта

Применение	Разбавление
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Фон

High mobility group protein B1 (HMGB1) is a ~24 kDa protein. Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy.

1. Yang, H. et al. (2013) Journal of leukocyte biology 93, 865-73. PMID: 23446148

2. Li, G. et al. (2013) Frontiers in immunology 4, 68. PMID: 23519706

3. Li, G. et al. (2013) Seminars in cancer biology 23, 380-90. PMID: 23994764

4. Lee, SA. et al. (2014) Yonsei medical journal 55, 1165-76. PMID: 25048472

5. Mitola, S. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 176, 12-5. PMID: 16365390

Примечание

For research use only.

Изображения

SDS-PAGE

SDS-PAGE for Anti-Mouse HMGB1 Antibody (DPH1.1)
Western blot

Western blot analysis was performed using anti-HMGB1 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human HMGB1 (Catalog No: HY200011)
Lane 2: negative control

Ссылки

Даташит

Anti-Mouse HMGB1 Recombinant Antibody (DPH1.1).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа