Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3) (MB823107)

Name: Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3)
Brand: abinScience
SKU: MB823107
Price: 126 USD
Availability: InStock

Datasheet Compartir producto Copiar información

Precio(USD):

Especificación:

20ug
50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo	MB823107
Reactividad de especies	Mouse
Aplicaciones	in vivo IFNAR-1 blockade, in vitro IFNAR-1 blockade, WB
Especie huésped	Rat
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	MAR1-5A3
Aplicaciones probadas	WB
Objetivo	Interferon alpha/beta receptor 1, Cytokine receptor family 2 member 1, Cytokine receptor class-II member 1, CRF2-1, IFN-R-1, IFNAR1, IFNAR, IFN-alpha/beta receptor 1, Type I interferon receptor 1
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P33896
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo	Interferon alpha/beta receptor 1 (IFNAR1) is a ~65 kDa protein. Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. 1. Kumar, KG. et al. (2003) The EMBO journal 22, 5480-90. PMID: 14532120 2. Uzé, G. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 4774-8. PMID: 1533935 3. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985 4. de Weerd, NA. et al. (2013) Nature immunology 14, 901-7. PMID: 23872679
Nota	For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-H4K5acK8ac monoclonal antibody at 1ug/mL on various samples.
Lane 1: 293T cell lysate
Lane 2: HCT116 cell lysate
Bioactivity

Detects recombinant mouse IFNAR1 (Catalog No: MB823012) in indirect ELISA

Referencias

Datasheet

Anti-Mouse IFN-alpha/beta R1 Recombinant Antibody (MAR1-5A3).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo