

| Каталожный номер | MV148014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Mouse IFNLR1 Polyclonal Antibody (MV148014) is a rabbit polyclonal antibody detecting IFNLR1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| Реактивность видов | Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Mouse IFNLR1 (Thr42-Ala221). | ||||||||
| Цель | Cytokine receptor class-II member 12, IFN-lambda-R1, CRF2-12, IFNLR1, IL28RA, IL-28 receptor subunit alpha, Cytokine receptor family 2 member 12, Interleukin-28 receptor subunit alpha, IL-28RA, Interferon lambda receptor 1, IFN-lambda receptor 1, IL-28R-alpha, LICR2, Likely interleukin or cytokine receptor 2 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q8CGK5 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Interferon lambda receptor 1 (IFNLR1) is a ~59 kDa protein. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. | ||||||||
| Примечание | For research use only. |
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