Anti-Mouse IL-23 p19 Recombinant Antibody (G23-8) (MV466013)

Name: Anti-Mouse IL-23 p19 Recombinant Antibody (G23-8)
Brand: abinScience
SKU: MV466013
Price: 191 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

MV466013

Reactividad de especies

Mouse

Aplicaciones

ELISA, FCM, Functional assay, Research in vivo

Especie huésped

Rat

Clonalidad

Monoclonal

Isotipo

IgG1, kappa

ID de clon

G23-8

Objetivo

IL-23 subunit alpha, IL-23-A, IL-23p19, IL23A, Interleukin-23 subunit alpha, Interleukin-23 subunit p19, SGRF

Nivel de endotoxinas

< 10 EU/mg

Pureza

>95% as determined by SDS-PAGE.

Productos asociados

pH 7.4 Dilution Buffer

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q9EQ14

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Envío

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Interleukin-23 subunit alpha (IL-23 p19) is a ~22 kDa protein. Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.

1. Oppmann, B. et al. (2000) Immunity 13, 715-25. PMID: 11114383

2. Wiekowski, MT. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 166, 7563-70. PMID: 11390512

3. Yen, D. et al. (2006) The Journal of clinical investigation 116, 1310-6. PMID: 16670770

4. Li, X. et al. (2010) Immunology letters 127, 100-7. PMID: 19900478

5. Happel, KI. et al. (2005) The Journal of experimental medicine 202, 761-9. PMID: 16157683

6. Mangan, PR. et al. (2006) Nature 441, 231-4. PMID: 16648837

Nota

For research use only

Imágenes

Referencias

Datasheet

Anti-Mouse IL-23 p19 Recombinant Antibody (G23-8).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo