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| カタログ番号 | MV466013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Mouse | ||||
| アプリケーション | ELISA, FCM, Functional assay, Research in vivo | ||||
| 宿主種 | Rat | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG1, kappa | ||||
| クローンID | G23-8 | ||||
| ターゲット | IL-23 subunit alpha, IL-23-A, IL-23p19, IL23A, Interleukin-23 subunit alpha, Interleukin-23 subunit p19, SGRF | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 関連製品 | pH 7.4 Dilution Buffer | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q9EQ14 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. | ||||
| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Interleukin-23 subunit alpha (IL-23 p19) is a ~22 kDa protein. Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells. 1. Oppmann, B. et al. (2000) Immunity 13, 715-25. PMID: 11114383 2. Wiekowski, MT. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 166, 7563-70. PMID: 11390512 3. Yen, D. et al. (2006) The Journal of clinical investigation 116, 1310-6. PMID: 16670770 4. Li, X. et al. (2010) Immunology letters 127, 100-7. PMID: 19900478 5. Happel, KI. et al. (2005) The Journal of experimental medicine 202, 761-9. PMID: 16157683 6. Mangan, PR. et al. (2006) Nature 441, 231-4. PMID: 16648837 | ||||
| 注意事項 | For research use only |
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