Anti-Mouse IL-23 p19 Recombinant Antibody (G23-8) (MV466013)

Name: Anti-Mouse IL-23 p19 Recombinant Antibody (G23-8)
Brand: abinScience
SKU: MV466013
Price: 191 USD
Availability: InStock

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Спецификация:

50ug
100ug
1mg

Количество:

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

MV466013

Реактивность видов

Mouse

Применения

ELISA, FCM, Functional assay, Research in vivo

Хозяинский вид

Rat

Клоональность

Monoclonal

Изотип

IgG1, kappa

ID клона

G23-8

Цель

IL-23 subunit alpha, IL-23-A, IL-23p19, IL23A, Interleukin-23 subunit alpha, Interleukin-23 subunit p19, SGRF

Уровень эндотоксинов

< 10 EU/mg

Чистота

>95% as determined by SDS-PAGE.

Связанные продукты

pH 7.4 Dilution Buffer

Очистка

Protein A/G purified from cell culture supernatant.

Номер доступа

Q9EQ14

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Доставка

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Interleukin-23 subunit alpha (IL-23 p19) is a ~22 kDa protein. Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.

1. Oppmann, B. et al. (2000) Immunity 13, 715-25. PMID: 11114383

2. Wiekowski, MT. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 166, 7563-70. PMID: 11390512

3. Yen, D. et al. (2006) The Journal of clinical investigation 116, 1310-6. PMID: 16670770

4. Li, X. et al. (2010) Immunology letters 127, 100-7. PMID: 19900478

5. Happel, KI. et al. (2005) The Journal of experimental medicine 202, 761-9. PMID: 16157683

6. Mangan, PR. et al. (2006) Nature 441, 231-4. PMID: 16648837

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-Mouse IL-23 p19 Recombinant Antibody (G23-8).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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