Anti-Mouse ST2/IL-33R Polyclonal Antibody (MX139014)

Name: Anti-Mouse ST2/IL-33R Polyclonal Antibody
Brand: abinScience
SKU: MX139014
Price: 96 USD
Availability: InStock

Datasheet Compartir producto Copiar información

Precio(USD):

Especificación:

20ug
50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

MX139014

Reactividad de especies

Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Mouse IL1RL1/ST2 (Ser27-Arg332).

Aplicaciones probadas

Objetivo

Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Interleukin-33 receptor alpha chain) (Lymphocyte antigen 84) (Protein ST2) (Protein T1)

Purificación

Purified by antigen affinity column.

Número de acceso

P14719

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Interleukin-1 receptor-like 1 (IL1RL1/ST2) is a ~64 kDa protein. Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages.

1. Chackerian, AA. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 2551-5. PMID: 17675517

2. Palmer, G. et al. (2008) Cytokine 42, 358-64. PMID: 18450470

3. Zhao, J. et al. (2012) Nature immunology 13, 651-8. PMID: 22660580

4. Osbourn, M. et al. (2017) Immunity 47, 739-751.e5. PMID: 29045903

5. Faas, M. et al. (2021) Immunity 54, 2531-2546.e5. PMID: 34644537

Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-IL1RL1 polyclonal antibody at 1µg/ml on various samples.
Lane 1: Hela cell lysate
Lane 2: SGC-7901 cell lysate
Lane 3: HUVEC cell lysate
Lane 4: HepG2 cell lysate
Lane 5: Mouse brain lysate

Referencias

Datasheet

Anti-Mouse ST2/IL-33R Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo