Anti-Mouse ST2/IL-33R Polyclonal Antibody (MX139014)

Name: Anti-Mouse ST2/IL-33R Polyclonal Antibody
Brand: abinScience
SKU: MX139014
Price: 96 USD
Availability: InStock

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

MX139014

Reactivité des espèces

Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Mouse IL1RL1/ST2 (Ser27-Arg332).

Applications testées

Cible

Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Interleukin-33 receptor alpha chain) (Lymphocyte antigen 84) (Protein ST2) (Protein T1)

Purification

Purified by antigen affinity column.

Numéro d'accès

P14719

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Interleukin-1 receptor-like 1 (IL1RL1/ST2) is a ~64 kDa protein. Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages.

1. Chackerian, AA. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 2551-5. PMID: 17675517

2. Palmer, G. et al. (2008) Cytokine 42, 358-64. PMID: 18450470

3. Zhao, J. et al. (2012) Nature immunology 13, 651-8. PMID: 22660580

4. Osbourn, M. et al. (2017) Immunity 47, 739-751.e5. PMID: 29045903

5. Faas, M. et al. (2021) Immunity 54, 2531-2546.e5. PMID: 34644537

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-IL1RL1 polyclonal antibody at 1µg/ml on various samples.
Lane 1: Hela cell lysate
Lane 2: SGC-7901 cell lysate
Lane 3: HUVEC cell lysate
Lane 4: HepG2 cell lysate
Lane 5: Mouse brain lysate

Reférences

Fiche technique

Anti-Mouse ST2/IL-33R Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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