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| カタログ番号 | MX139014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse IL1RL1/ST2 (Ser27-Arg332). | ||||||||
| テスト済みアプリケーション | WB | ||||||||
| ターゲット | Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Interleukin-33 receptor alpha chain) (Lymphocyte antigen 84) (Protein ST2) (Protein T1) | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P14719 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Interleukin-1 receptor-like 1 (IL1RL1/ST2) is a ~64 kDa protein. Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. 1. Chackerian, AA. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 2551-5. PMID: 17675517 2. Palmer, G. et al. (2008) Cytokine 42, 358-64. PMID: 18450470 3. Zhao, J. et al. (2012) Nature immunology 13, 651-8. PMID: 22660580 4. Osbourn, M. et al. (2017) Immunity 47, 739-751.e5. PMID: 29045903 5. Faas, M. et al. (2021) Immunity 54, 2531-2546.e5. PMID: 34644537 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-IL1RL1 polyclonal antibody at 1µg/ml on various samples.
Lane 1: Hela cell lysate
Lane 2: SGC-7901 cell lysate
Lane 3: HUVEC cell lysate
Lane 4: HepG2 cell lysate
Lane 5: Mouse brain lysate
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