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Anti-Mouse IL4I1 Polyclonal Antibody (MP675014)

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Aperçu
Numéro de catalogueMP675014
Description
Anti-Mouse IL4I1 Polyclonal Antibody (MP675014) is a rabbit polyclonal antibody detecting IL4I1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesMouse
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Mouse IL4I1 (Asp40-Gly507).
Cible L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (EC 1.4.3.25) (Interleukin-4-induced protein 1) (IL4-induced protein 1) (mIL4I1) (Protein Fig-1) (mFIG1)
Purification Purified by antigen affinity column.
Numéro d'accès O09046
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

L-amino-acid oxidase (IL4I1) is a ~70 kDa protein. Secreted L-amino-acid oxidase that acts as a key immunoregulator. Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively. Also has weak L-arginine oxidase activity. Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR. IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer.

1. Sadik, A. et al. (2020) Cell 182, 1252-1270.e34. PMID: 32818467
2. Mason, JM. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 4561-7. PMID: 15383589
3. Lasoudris, F. et al. (2011) European journal of immunology 41, 1629-38. PMID: 21469114
4. Bod, L. et al. (2017) Oncoimmunology 6, e1278331. PMID: 28405502
5. Cousin, C. et al. (2015) European journal of immunology 45, 1772-82. PMID: 25778793
6. Bod, L. et al. (2018) Journal of immunology (Baltimore, Md. : 1950) 200, 1027-1038. PMID: 29288206
7. Yue, Y. et al. (2015) PloS one 10, e0142979. PMID: 26599209
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Mouse IL4I1 Polyclonal Antibody

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