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| カタログ番号 | MP675014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse IL4I1 Polyclonal Antibody (MP675014) is a rabbit polyclonal antibody detecting IL4I1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse IL4I1 (Asp40-Gly507). | ||||||||
| ターゲット | L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (EC 1.4.3.25) (Interleukin-4-induced protein 1) (IL4-induced protein 1) (mIL4I1) (Protein Fig-1) (mFIG1) | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O09046 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | L-amino-acid oxidase (IL4I1) is a ~70 kDa protein. Secreted L-amino-acid oxidase that acts as a key immunoregulator. Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively. Also has weak L-arginine oxidase activity. Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR. IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer. 1. Sadik, A. et al. (2020) Cell 182, 1252-1270.e34. PMID: 32818467 2. Mason, JM. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 4561-7. PMID: 15383589 3. Lasoudris, F. et al. (2011) European journal of immunology 41, 1629-38. PMID: 21469114 4. Bod, L. et al. (2017) Oncoimmunology 6, e1278331. PMID: 28405502 5. Cousin, C. et al. (2015) European journal of immunology 45, 1772-82. PMID: 25778793 6. Bod, L. et al. (2018) Journal of immunology (Baltimore, Md. : 1950) 200, 1027-1038. PMID: 29288206 7. Yue, Y. et al. (2015) PloS one 10, e0142979. PMID: 26599209 | ||||||||
| 注意事項 | For research use only. |
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