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| カタログ番号 | MV546014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse KISS1R Polyclonal Antibody (MV546014) is a rabbit polyclonal antibody detecting KiSS-1 receptor; KiSS-1R; G-protein coupled receptor 54; G-protein coupled receptor OT7T175; mOT7T175; Kisspeptins receptor; Metastin receptor; Kiss1r; Gpr54 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant mouse KISS1R (Ala2-Trp43&Leu102-Lys116&His181-Ala203&Val284-Lys305). | ||||||||
| ターゲット | KiSS-1 receptor; KiSS-1R; G-protein coupled receptor 54; G-protein coupled receptor OT7T175; mOT7T175; Kisspeptins receptor; Metastin receptor; Kiss1r; Gpr54 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q91V45 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | KiSS-1 receptor (KISS1R) is a ~43 kDa protein. Receptor for kisspeptins (kisspeptin-10, kisspeptin-13, kisspeptin-14 and metastin/kisspeptin-54). The hypothalamic KISS1/KISS1R signaling system plays a central role in the regulation of the hypothalamic-pituitary-gonadal reproductive axis by modulating the secretion of gonadotropin-releasing hormone (GnRH) from GnRH neurons. In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leading to phospholipase C (PLC) activation, and hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2). The subsequent rise in intracellular calcium levels results in the inhibition of inward rectifier potassium channels and activation of TRPC-like cation channels, leading to GnRH neurons depolarization and stimulation. In addition to this pathway, kisspeptin also triggers G(q)-independent signaling via beta-arrestin, leading to MAPK cascade activation and ERK1/ERK2 phosphorylation. 1. Stafford, LJ. et al. (2002) Cancer research 62, 5399-404. PMID: 12359743 2. Seminara, SB. et al. (2003) The New England journal of medicine 349, 1614-27. PMID: 14573733 3. Funes, S. et al. (2003) Biochemical and biophysical research communications 312, 1357-63. PMID: 14652023 4. Messager, S. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 1761-6. PMID: 15665093 5. Zhang, C. et al. (2008) The Journal of neuroscience : the official journal of the Society for Neuroscience 28, 4423-34. PMID: 18434521 6. Liu, X. et al. (2008) Endocrinology 149, 4605-14. PMID: 18483150 7. Ahow, M. et al. (2014) Endocrinology 155, 4433-46. PMID: 25147978 8. Li, Z. et al. (2024) Nature communications 15, 1300. PMID: 38346942 | ||||||||
| 注意事項 | For research use only. |
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