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| カタログ番号 | MW360014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse LEP/Leptin (Val22-Cys167). | ||||||||
| ターゲット | Leptin, Obesity factor, Lep | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P41160 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Leptin is a ~18 kDa protein. Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. 1. Cowley, MA. et al. (2001) Nature 411, 480-4. PMID: 11373681 2. Bates, SH. et al. (2003) Nature 421, 856-9. PMID: 12594516 3. Otero, M. et al. (2005) Arthritis research & therapy 7, R581-91. PMID: 15899045 4. Gonzalez, RR. et al. (2006) The Journal of biological chemistry 281, 26320-8. PMID: 16825198 5. Ramadori, G. et al. (2010) Cell metabolism 12, 78-87. PMID: 20620997 6. Ducy, P. et al. (2000) Cell 100, 197-207. PMID: 10660043 7. Cassano, S. et al. (2014) Metabolism: clinical and experimental 63, 1272-9. PMID: 25060689 8. Flak, JN. et al. (2014) Nature neuroscience 17, 1744-1750. PMID: 25383904 9. Chehab, FF. et al. (1996) Nature genetics 12, 318-20. PMID: 8589726 | ||||||||
| 注意事項 | For research use only. |
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