

| Каталожный номер | MF797014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Mouse LRP5 Polyclonal Antibody (MF797014) is a rabbit polyclonal antibody detecting LRP5 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
|
||||||||
| Реактивность видов | Human, Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Mouse LRP5 (Ser31-Ser287). | ||||||||
| Цель | Low-density lipoprotein receptor-related protein 5, LRP5, LRP-5, LRP7, LRP-7, Low-density lipoprotein receptor-related protein 7, LR3 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q91VN0 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
||||||||
| Информация об использовании продукта |
| ||||||||
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Low-density lipoprotein receptor-related protein 5 (LRP5) is a ~178 kDa protein. Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs. 1. Kato, M. et al. (2002) The Journal of cell biology 157, 303-14. PMID: 11956231 2. Kelly, OG. et al. (2004) Development (Cambridge, England) 131, 2803-15. PMID: 15142971 | ||||||||
| Примечание | For research use only. |
Свяжитесь с нами для индивидуальных предложений, оптовых запросов и других вопросов.
Почта: [email protected]
+86-027-65523339
Building C, No. 666, Shen Dun Si Lu, Wuhan, 430206, China
中文
English
한국어
日本語
Español
Français
Русский