Anti-Mouse LY6E/SCA-2 Recombinant Antibody (SAA1998), APC (MS714137)

Name: Anti-Mouse LY6E/SCA-2 Recombinant Antibody (SAA1998), APC
Brand: abinScience
SKU: MS714137
Price: 290 USD
Availability: InStock

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Numéro de catalogue	MS714137
Reactivité des espèces	Human, Mouse
Applications	FCM
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a, kappa
ID de clone	SAA1998
Conjugaison	APC
Cible	SCA-2, TSA-1, 9804, Retinoic acid-induced gene E protein, TSA1, Lymphocyte antigen 6E, Ly-6E, Stem cell antigen 2, Thymic shared antigen 1, SCA2, RIGE, LY6E, RIG-E
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), APC
Numéro d'accès	Q64253
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Lymphocyte antigen 6E (LY6E/SCA-2) is a ~14 kDa protein. GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of murine coronavirus, mouse hepatitis virus, by interfering with spike protein-mediated membrane fusion. Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. 1. Noda, S. et al. (1996) The Journal of experimental medicine 183, 2355-60. PMID: 8642345 2. Kosugi, A. et al. (1998) The Journal of biological chemistry 273, 12301-6. PMID: 9575182 3. Pfaender, S. et al. (2020) Nature microbiology 5, 1330-1339. PMID: 32704094 4. Bacquin, A. et al. (2017) Journal of virology 91. PMID: 28679758 5. Langford, MB. et al. (2018) Scientific reports 8, 3961. PMID: 29500366 6. Wu, M. et al. (2015) The Journal of biological chemistry 290, 24509-18. PMID: 26276394
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Mouse LY6E/SCA-2 Recombinant Antibody (SAA1998), APC.pdf

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