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| カタログ番号 | MS714107 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||
| アプリケーション | FCM, WB | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1998 | ||||
| ターゲット | SCA-2, TSA-1, 9804, Retinoic acid-induced gene E protein, TSA1, Lymphocyte antigen 6E, Ly-6E, Stem cell antigen 2, Thymic shared antigen 1, SCA2, RIGE, LY6E, RIG-E | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q64253 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
| ||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Lymphocyte antigen 6E (LY6E/SCA-2) is a ~14 kDa protein. GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of murine coronavirus, mouse hepatitis virus, by interfering with spike protein-mediated membrane fusion. Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. 1. Noda, S. et al. (1996) The Journal of experimental medicine 183, 2355-60. PMID: 8642345 2. Kosugi, A. et al. (1998) The Journal of biological chemistry 273, 12301-6. PMID: 9575182 3. Pfaender, S. et al. (2020) Nature microbiology 5, 1330-1339. PMID: 32704094 4. Bacquin, A. et al. (2017) Journal of virology 91. PMID: 28679758 5. Langford, MB. et al. (2018) Scientific reports 8, 3961. PMID: 29500366 6. Wu, M. et al. (2015) The Journal of biological chemistry 290, 24509-18. PMID: 26276394 | ||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-LY6E/SCA-2 monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human LY6E/SCA-2 (Catalog No: HS714011), 50ng
Lane 2: recombinant human LY6E/SCA-2 (Catalog No: HS714011), 30ng
Lane 3: recombinant human LY6E/SCA-2 (Catalog No: HS714011), 20ng
Lane 4: recombinant human LY6E/SCA-2 (Catalog No: HS714011), 10ng
SDS-PAGE for Anti-Mouse LY6E/SCA-2 Recombinant Antibody (SAA1998)
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